Extract of Ginkgo biloba added to haloperidol was effective for positive symptoms in refractory schizophrenia.

Setting A psychiatric hospital in Beijing, China. Patients 112 Han Chinese patients who were 18–60 years of age, had schizophrenia according to DSM-III-R criteria for >5 years, were resistant to treatment, and had a Clinical Global Impressions scale score of >4. Exclusion criteria were medical illness, alcohol or drug abuse, receipt of vitamin C or E within 1 week of the start of the study, pregnancy, breastfeeding, or depressive symptoms. 109 patients (mean age 44 y, 58% men) completed a 1 week placebo run in period; 103 (94%) completed the study; all patients were included in the analysis of clinical response.